Hydrazinecarbodithioic acid methyl ester

Name	methyldithiocarbazate
Synonyms	methyldithiocarbazate methyl N-aminocarbamodithioate Methyl hydrazinecarbodithioate Mercapto(methylthio)methanonehydrazone Hydrazinecarbodithioic acid methyl ester {[(methylsulfanyl)methanethioyl]amino}amine 1-[(Methylthio)(mercapto)methylene]hydrazine Hydrazine-1-dithiocarboxylic acid methyl ester
CAS	5397-03-5

EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Application	methyl hydrazine dithioformate is a pharmaceutical intermediate, which can be prepared by reacting hydrazine hydrate, carbon disulfide and dimethyl sulfate. It has been reported that it can be used to prepare a kind of amine thiourea anticancer drug.
preparation	Add 60ml of water and 50ml of isopropanol in a ML three-neck flask, and cool in a water bath, add 49.5g(0.75mol) potassium hydroxide in portions, stir to make it fully soluble, slowly add 39g(0.75mol)85% hydrazine monohydrate at ≤ 20 ℃, add it in 10 minutes, remove the water bath for ice bath, Dropwise add ice-cold 100g (57.5 mol) carbon disulfide at 10 °c for 0.75 minutes, add mixed 2 hours, and then raise the temperature to 15 °c, ice-cold 94 was added dropwise over 2.5 hours. 5G (0.75mol) dimethyl sulfate, after adding, and then continue to stir 1 hours. The resultant white precipitate was filtered, rinsed with a small amount of ice water, dried in vacuo, and recrystallized from dichloromethane to give 55g of colorless flaky crystals in a yield of 60% at mp.81 -82 °c.

Last Update：2024-04-09 02:00:23

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CAS: 5397-03-5
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Product Name: methyldithiocarbazate Request for quotation
CAS: 5397-03-5
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228

Wechat: 13651600618
WhatsApp: +8613651600618

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Hydrazinecarbodithioic acid methyl ester

Hydrazinecarbodithioic acid methyl ester Request for Quotation